Web519 Background: KRAS, the most frequently mutated oncogene in cancer, is a key mediator of the RAS/MAPK signaling cascade that promotes cellular growth and proliferation. KRAS mutations occur in approximately 90% of pancreatic cancer, and approximately 2% of these are KRASG12C mutations. Adagrasib, an investigational agent, is a KRASG12C inhibitor … WebJan 18, 2024 · NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring …

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WebThe commonest adverse events exceeding 20% in the combined regimen were anemia (46%), fatigue (37%) and nausea (28%). Grade > 3 anemia was more commonly seen in the combination regimen 15.1% vs 5.3%, and pulmonary embolism occurred in 6.5% v 1.8%. No difference in cardiovascular adverse events occurred between groups. WebNov 18, 2014 · CDC ship caligula

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WebOct 21, 2024 · Background: The prognoses with respect to mortality and hepatic and nonhepatic outcomes across the histologic spectrum of nonalcoholic fatty liver disease (NAFLD) are not well defined. Methods: We prospectively followed a multicenter patient population that included the full histologic spectrum of NAFLD. The incidences of death … WebJan 18, 2024 · NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. WebNEJM AI Grand Rounds Dr. Lily Peng has driven major medical AI efforts along the long and arduous path from ideation to deployment. From publishing a landmark study in … ship call outs