Destabilization of medial meniscus
WebApr 7, 2024 · 按文献方法采用内侧半月板失稳(destabilization of medial meniscus，DMM)手术诱导建立KOA模型[9]，简述如下：右膝关节内侧髌韧带与内侧副韧带之间开0.5 cm切口，显微镜下暴露、剪断内侧半月板胫骨韧带，缝合切口。 WebApr 10, 2024 · In this study, a destabilization of the medial meniscus (DMM)-induced OA model was constructed, and SDF-1α expression in the OA model was evaluated. The CXCR4 receptor antagonist AMD3100 was used to block SDF-1α, and changes in subchondral bone and the expression of BMSCs in subchondral bone in the OA model …
Destabilization of medial meniscus
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Webdifferences in a destabilized medial meniscus osteoarthritis model. Methods: Male and Female mice receive either a destabilized medial meniscus or sham procedure resulting in groups of n=5 (n=20 total). The mice were then allowed to explore a specialized gait arena to collect spatiotemporal data. Gait results were analyzed for gender differences. WebDestabilization of the medial meniscus (DMM) was performed on the right knees of 2 month-old male Matn1-/- (n = 11) and Matn1+/+ (n = 9) mice. A) mRNA levels of type II …
WebDesign: Acomys received destabilization of the medial meniscus (DMM) surgery (n = 11) or a skin incision (n = 10). Gait testing occurred at 4, 6, 8, 10, and 12 weeks after surgery. At endpoint, joints were processed for histology to assess cartilage damage. Results: Following joint injury, Acomys with DMM surgery altered their walking patterns ... WebOsteoarthritis Mouse Model of Destabilization of the Medial Meniscus This chapter describes the surgical procedure for destabilization of medial meniscus in mice. Details on subsequent microCT and histological analysis are also provided, as well as details on osteoarthritis evaluation.
WebAug 12, 2013 · 1. Make an incision of the skin on the medial side of patellar ligament using a #15 blade. 2. Fold back the skin and locate the patellar ligament (Figure 1). 3. Make an … WebSep 29, 2024 · Destabilization of the medial meniscus (DMM) is commonly used as a surgical model of OA in the mouse . In this model transection of the mediomeniscotibial ligament (MMTL) results in a slowly progressing …
WebApr 10, 2024 · Methods: In the present study, C57BL/6J mice were divided into the following three groups: the sham control, destabilization of the medial meniscus (DMM), and AMD3100-treated DMM (DMM + AMD3100) groups. The mice were sacrificed after 2 or 8 weeks, and samples were collected for histological and immunohistochemical analyses. …
WebFeb 10, 2024 · We further investigated whether kindlin-2 loss impacts progression of a destabilization of the medial meniscus (DMM)-induced OA model. At 2 months of age, the K2fl/fl; AggrecanCreERT2 mice were... dercos anticaspa vichy shp int200mlWebJan 1, 2015 · Destabilization of the medial meniscus (DMM) surgery and tissue processing post-DMM. DMM surgeries were performed, as described 32, 33 , in 12-week-old male IKKα cKO and WT littermates. Power... dercos shampooing traitantWebJun 28, 2024 · A mouse OA model was induced using destabilization of the medial meniscus (DMM) surgery, chondrocyte ferroptosis was induced using an intra-articular injection of Erastin, and Met (200 mg/kg/day) was intragastrically administered for 8 weeks after surgery. H&E and Safranin O‑fast green staining were used to evaluate cartilage … dercos energising shampooWebdifferences in a destabilized medial meniscus osteoarthritis model. Methods: Male and Female mice receive either a destabilized medial meniscus or sham procedure resulting … chronicle publications ltdWebAbstract: Destabilization of medial meniscus (DMM) surgical instability models of osteoarthritis (OA) have been underutilized despite having many inherent advantages. At present, there is a lack of studies clarifying cartilage degenerative changes induced by DMM in rats, which would further verify a greater use of this model. Therefore, der computer powerpointWebAnimals (mice or rats) are anesthetized with Isoflurane and the right knee area and lower leg are prepared for surgery. For the surgical destabilization of the medial meniscus (DMM), a skin incision is made from the distal patella to the proximal tibial plateau. The joint capsule immediately medial to the patellar tendon is incised and spread ... dercos shampooing antipelliculaireder county