Cisplatin hydration protocol

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August undefined, 2024

WebJul 15, 2015 · Hydration is recommended to induce diuresis and reduce the concentration of cisplatin in the kidneys. Isotonic saline (0.9% sodium chloride) is recommended for hydration fluids, and many... WebCisplatin Injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials. Each 50 mL or 100 mL amber vial of infusion concentrate …

Staying Hydrated After Moderate to High-Dose Cisplatin

WebFeb 16, 2016 · Cisplatin CCRT regimen comprised of hospital admission with intravenous cisplatin (100 mg/m 2 on days 1, 22, and 43 during radiotherapy) and is the standard care in our hospital. Patients are pre-hydrated 12 h prior to treatment, and posthydrated for 2 days with at least 3.5 L of 0.9% saline with 60 mmol/L of KCl and 30 mmol/L of MgSO 4 , … WebFor cisplatin, hydration is always indicated and mannitol may be useful in selected settings. Furosemide is probably not generally useful. For carboplatin, hydration is … dr phay osu

A Systematic Review of Strategies to Prevent Cisplatin …

WebCisplatin is administered in 500mL sodium chloride 0.9% over 60 minutes following the pre and post hydration protocol below. Infusion Fluid & Additives Volume Infusion Time Sodium Chloride 0.9% 1000mL 60 minutes Mannitol 20% 200mL 10 minutes OR Mannitol 10% 400mL 15 minutes WebSep 1, 2024 · Ensure adequate hydration before, during, and after Cisplatin for injectionadministration [see Dosage and Administration ( 2.1 )]. Measure serum creatinine, blood urea nitrogen, creatinine clearance, and serum electrolytes including magnesium prior to initiating therapy, and as clinically indicated. http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf#:~:text=Hydration%20is%20required%20to%20minimize%20nephrotoxicity.13%20The%20manufacturer,see%20the%20%E2%80%9CNephrotoxicity%E2%80%9D%20paragraph%20following%20Side%20Effects%20table. dr phay columbus ohio

Cisplatin Mouse Models: Treatment, Toxicity and Translatability …

Staying Hydrated Before Moderate to High-Dose Cisplatin

WebAug 26, 2024 · b Hydration is required with supplemental electrolytes pre- and post-administration of Cisplatin. c For Bleomycin: Consider premedication for anaphylactoid … WebThe new hydration protocol with supplemented magnesium with mannitol without furosemide was an independent factor for the protection against nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced NSCLC [HR 0.232 (95% CI: 0.055-0.986), P=0.039]. dr phattWebCisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the administration of cisplatin, mannitol (20%, 200 ml) was administered as forced diuresis over 30 min. And magnesium sulfate (8 mEq) was added to pre-hydration. Results: dr phay st thomas hendersonville tn

"Webprotocol. The best tumour response rates were as follows (arm A and arm B): complete response: 2.4 and 2.3%; partial response: 39 and 20.4%; stable disease: 26.8 and 13.6%; and progressive disease: 31.8 and 45.4%. The median progression-free and overall survival were 3.9 and 12.3 months in arm A, respectively, 3.1 and 7.7 months in " - Cisplatin hydration protocol

Cisplatin hydration protocol

A Systematic Review of Strategies to Prevent Cisplatin‐Induced ...

WebHydration is essential for all patients to prevent cisplatin-induced nephrotoxicity. Specifically, short-duration, low-volume, outpatient hydration with magnesium … WebThe in-patient hydration protocol was 6000 ml of normal saline with 60 mmol/L KCL, and 30 mmol/L MgSO4 over 24 to 28 hours, and the out-patient hydration was 4000 ml of normal saline over 6 hours. Results: The mean age was 56 years.

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WebDec 16, 2024 · Cisplatin is a very effective and widely used anti-tumor drug that carries a significant risk of nephrotoxicity. Cisplatin-induced nephrotoxicity is a primary … WebPretreatment hydration: 1-2 L fluid infused for 8-12 hr before dose May use concomitant amifostine to decrease nephrotoxicity Do not repeat course until SCr <1.5 mg/dL [<133 micromoles/L] or BUN...

WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting. {{configCtrl2.info.metaDescription}} Medline ® Abstract for Reference 52 of 'Cisplatin nephrotoxicity' 52 PubMed TI … Cisplatin dose and the AUC of UP were less satisfactory predictors of the change in … The lowest dose categories of cisplatin (≤100 and 101-250 mg/m(2)) are … The laboratory observation that forced hydration and diuresis may prevent … WebCisplatin is a chemotherapeutic drug used to treat various malignancies (1). It is renally excreted and requires concurrent intravenous hydration to prevent nephrotoxicity, its …

WebThis regimen must be administered by a clinician trained in the use of chemotherapy, who should use independent medical judgment in the context of individual circumstances to make adjustments, as necessary.

WebApr 24, 2024 · Cisplatin is a platinum-based alkylating compound that reacts with DNA to form interstrand cross-links and intrastrand bifunctional N-7 DNA adducts at d (GpG) and d (ApG) 3. Cisplatin is renally excreted and can accumulate in the renal proximal tubules, leading to nephrotoxicity.

WebPre-hydration fluids should be administered immediately before cisplatin infusion is started and post hydration fluids should be administered immediately after cisplatin infusion … dr phaythouneWebJun 23, 2024 · Depending on the protocol, 1 - 2 litres pre-hydration. The patient must have urinated a litre minimum before we proceed. Our cisplat goes in 250 mls usually giving … dr phaythoune chothmounethinhWebPACLitaxel/CISplatin for Cervical Cancer. Each section is described in more detail using the associated letters (continued). 3 Continued next page. D. NCCN Supportive Care This … college football playoff 2015WebCisplatin pre-hydration as follows - furosemide 40mg oral - sodium chloride 0.9% 1000ml with 16mmol magnesium sulphate and 20mmol potassium chloride over 60 minutes Cisplatin post hydration as follows - sodium chloride 0.9% 1000ml with 16mmol magnesium sulphate and 20mmol potassium chloride over 60 minutes college football playoff 2013WebMay 18, 2024 · Cisplatin 50-100 mg/m 2 IV over 30min with vigorous hydration; repeat every 3wk or Carboplatin AUC 5-7 IV over 30min; repeat every 3wk (see the Carboplatin AUC Dose Calculation [Calvert... dr. phaythoune chothmounethinh mdWebApr 21, 2024 · Hydration: Due to the potential for nephrotoxicity associated with cisplatin, pretreatment hydration with 1 to 2 L of fluid is recommended prior to cisplatin ... and cisplatin dose reduced if <60 mL/min. In the original protocol, cisplatin dose was reduced by 25% if the serum creatinine level during the prior cycle was 1.6 to 2 mg/dL, and ... dr p h barrowhttp://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf dr. phay osu