Cisplatin gsh

WebOxidative stress caused by cisplatin, evidenced by increases in kidney tissues malondialdehyde (MDA) content, cytochrome P450 E1 (CYP2E1), renal 4-hydroxynonenal (4-HNE) levels and decreases of glutathione (GSH) and superoxide dismutase (SOD) contents, was significantly ameliorated by AGBE pretreatment. Webized GSH concentration as compared to cisplatin alone (table 2). The renal GSH and oxidized GSH concentrations in lipoic acid alone treated group were 19.93”2.39 and …

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin ...

Web(GSH) transferase activity of GST P1-1. Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity. Furthermore, it is well known that GST P1-1 binding to the c-Jun N-terminal kinase (JNK) inhibits JNK phosphory- WebFeb 12, 2024 · Cisplatin, [Pt (NH 3) 2 Cl 2] (CDDP), is a potent chemotherapeutic agent used for several types of cancer, e.g. carcinoma of the ovary, testicle, head and neck, bones, brain, lymph node, and skin. 1,2 CDDP still represents the elective cytotoxic agent for the treatment of the carcinoma of the ovary, which is the leading cause of death … green frog gardening and maintenance https://turnersmobilefitness.com

Intracellular glutathione-depleting polymeric micelles for cisplatin …

WebAug 8, 2010 · Cisplatin can bind to the thiol group of intracellular glutathione (GSH) and this reaction is considered important for the inactivation of cisplatin . However, Gibson and coworkers recently suggested that binding of cisplatin to GSH is not the most important cellular interaction for inactivation ( 17 ). WebIndeed, GSH can bind cisplatin forming cisplatin-GSH adducts which are exported from the cells through the multidrug resistance protein-2 (MRP-2) efflux pump, thus reducing the intracellular ... WebNov 27, 2024 · Cisplatin is the first-line chemotherapy treatment for those patients, however, resistance to this drug is a common and yet not fully understood phenomenon. Aiming to shed new light into this puzzle, we used established normal and malignant lung cell lines displaying different sensitivity towards cisplatin treatment. flush mount cluster bulb lighting

Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects ... - RxList

Category:Doseâ Dependent Protection by Lipoic Acid against …

Tags:Cisplatin gsh

Cisplatin gsh

A structure-based mechanism of cisplatin resistance …

WebThe therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers. Intracellular glutathione (GSH) detoxification of cisplatin under the catalysis of … WebFeb 17, 2024 · The results showed that levels of glutamine, glutamate, and glutathione (GSH), a key drug resistance mediator synthesized from glutamate, were significantly elevated in A2780cis cells than those in A2780 cells. Furthermore, glutamine starvation decreased the GSH levels and CDDP resistance in A2780cis cells.

Cisplatin gsh

Did you know?

WebApart from GSH-conjugates, cisplatin can also be detoxified by binding to metallothioneins. Nevertheless, J82 did not show any difference in the amount of Pt-adducts between parental and LTT cells despite increased MT1B levels. However, we found metallothioneins mainly overexpressed in RT-112-LTT, suggesting that these cells evade cisplatin ... WebNov 1, 2015 · Increased GSH level has been associated with cisplatin resistance [11], [12], [13]. Cystine, the rate-limiting amino acid for GSH synthesis, is transported by the xc − system composed of heavy subunit F42hc, a common component for amino acid transport and the active subunit xCT [21].

WebPubMed Central (PMC) WebApr 1, 2024 · The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers. Intracellular glutathione (GSH) detoxification of cisplatin under the catalysis of …

WebEbselen is a seleno-organic compound with documented cytoprotective properties. Little work has been done, however, demonstrating ebselen's cytoprotective prop WebThree mechanisms have been proposed for the role of glutathione (GSH) in regulating cisplatin (CDDP) sensitivities that affects its ultimate cell-killing ability: (i) GSH may …

WebNov 27, 2024 · It is well established that one of the main factors that promote intracellular cisplatin detoxification is GSH, since it can bind covalently to the drug and prevent it to …

Webized GSH concentration as compared to cisplatin alone (table 2). The renal GSH and oxidized GSH concentrations in lipoic acid alone treated group were 19.93”2.39 and 1.14”0.12 nmoles/mg protein which were close to control values. Superoxide dismutase activity in the kidney significantly decreased (62% of control) in cisplatin-treated rats ... green frogfishWebMar 13, 2006 · Cisplatin is one of the most widely used chemotherapeutic drugs for treating cancer. Initially, platinum-based therapies are very effective in treating a wide array of cancers; however, recurrence and … flush mount concrete kitWebAug 10, 2024 · Overall, our data suggest that cisplatin treatment could positively select cancer cells which are independent from GSH for the maintenance of redox balance, and thus less sensitive to cisplatin-induced oxidative stress, opening new scenarios for the GSH pathway as a therapeutic target in HGSOC. Keywords: green frog factsWebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. flush mount corner guardsWebMar 10, 2024 · Considering glutathione (GSH) is the most abundant source of thiols in tumor cells and the concentration of GSH in cisplatin-resistant cells is frequently higher than that in cisplatin-sensitive cells, it is of great significance to control the GSH level in cancer cells for cisplatin-based treatment toward cisplatin-resistant cancers [7], [30], … green frog green frog what do you seeWebJul 1, 2013 · GSH concentration was measured with UV-Visible double beam spectrophotometer, using the Ellman’s method. The level of GSH was lowered upon addition of cisplatin to plasma and cytosolic... flush mount copper ceiling lightWebResults: Serum GSH content depleted significantly after a total dose of 4 Gy and 10 Gy of radiotherapy with a single dose of cisplatin, which was significantly lesser in NR than of CR patients. Similarly, Olive Tail Moment, the index of DNA damage, indicated significantly higher values in the fifth fraction of radiotherapy (5-RT) than in ... flush mount copper outdoor light